Synthetic Biology
based on standard parts
iGEM 2013 Team Information
| Team Name: | Fudan |
| Team Code: | 110041 |
| Schools: | www.fudan.edu.cn |
| Kind: | Collegiate | Application Date: 2013-03-31 |
| Division: | iGEM | Acceptance Date: 2013-05-20 08:52:09 |
| Region: | Asia |
| Country: | CHINA |
| Section: | Overgraduate |
| Jamboree: | iGEM 2013 Asia
iGEM 2013 Championship
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Your iGEM 2013 team application was accepted by iGEM Headquarters on 2013-05-20 08:52:09.
However, your registration is not complete until your team registration fee is paid. See how to pay your fees below. |
| Assigned Track: Foundational Advance
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ALeader: leading the advance of RNA synthetic biology
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| RNA regulation patterns, which have not been fully understood so far, is a research hotspot still deserving exploiting. A recently-discovered riboswitch ALeader updated our ideas by its delicate, 75nt-structure consisting of an aptamer, a recombination site, and even a bicistron motif. Inspired by this natural design, we proposed a series of novel strategies this summer, with dynamic rather than static perspectives. Guided by the theoretical study on functional multistable states and semi-static states of a riboswitch, and the kinetics involving impacts from other systems such as CRISPR, RNA polymerases, ribosomes, and degradation complex, the ALeader-based functional multi-phase and tricistron switches are designed. We also tried to regulate aptamer’s function by manipulating its working environment instead of itself, with SpinachALeader-based real-time monitors to avoid the signal distortion. Furthermore, to demonstrate the advantages of RNA biobricks, we constructed an antibiotic-detector with ALeader, optimized by a network with a RNA-OUT/IN translational regulatory system.
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| Primary PI [Required]
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| xmding74 | Xiaoming Ding | |
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| Secondary PI [Recommended]
More... |
| None designated
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| Instructors
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| Ruoyu | Ruoyu Luo | |
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| kazaf | Jun Wang | |
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| Student Leaders |
| None designated |
| This range of part numbers has been assigned to your team for use during the summer: BBa_K1100000 to BBa_K1100999
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