Synthetic Biology
based on standard parts
iGEM 2013 Team Information
Team Name: | Fudan |
Team Code: | 110041 |
Schools: | www.fudan.edu.cn |
Kind: | Collegiate | Application Date: 2013-03-31 |
Division: | iGEM | Acceptance Date: 2013-05-20 08:52:09 |
Region: | Asia |
Country: | CHINA |
Section: | Overgraduate |
Jamboree: | iGEM 2013 Asia iGEM 2013 Championship
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Your iGEM 2013 team application was accepted by iGEM Headquarters on 2013-05-20 08:52:09.
However, your registration is not complete until your team registration fee is paid. See how to pay your fees below. |
Assigned Track: Foundational Advance
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ALeader: leading the advance of RNA synthetic biology
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RNA regulation patterns, which have not been fully understood so far, is a research hotspot still deserving exploiting. A recently-discovered riboswitch ALeader updated our ideas by its delicate, 75nt-structure consisting of an aptamer, a recombination site, and even a bicistron motif. Inspired by this natural design, we proposed a series of novel strategies this summer, with dynamic rather than static perspectives. Guided by the theoretical study on functional multistable states and semi-static states of a riboswitch, and the kinetics involving impacts from other systems such as CRISPR, RNA polymerases, ribosomes, and degradation complex, the ALeader-based functional multi-phase and tricistron switches are designed. We also tried to regulate aptamer’s function by manipulating its working environment instead of itself, with SpinachALeader-based real-time monitors to avoid the signal distortion. Furthermore, to demonstrate the advantages of RNA biobricks, we constructed an antibiotic-detector with ALeader, optimized by a network with a RNA-OUT/IN translational regulatory system.
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Primary PI [Required]
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xmding74 | Xiaoming Ding | |
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Secondary PI [Recommended]
More... |
None designated
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Instructors
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Ruoyu | Ruoyu Luo | |
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kazaf | Jun Wang | |
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Student Leaders |
None designated |
This range of part numbers has been assigned to your team for use during the summer: BBa_K1100000 to BBa_K1100999
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