Synthetic Biology

based on standard parts

iGEM 2013 Team Information

Team Name: Fudan
Team Code:110041
Schools:
www.fudan.edu.cn
Kind:CollegiateApplication Date:  2013-03-31
Division:iGEMAcceptance Date: 2013-05-20 08:52:09
Region:Asia
Country:CHINA
Section:Overgraduate
Jamboree:iGEM 2013 Asia
iGEM 2013 Championship

Team Registration
Your iGEM 2013 team application was accepted by iGEM Headquarters on 2013-05-20 08:52:09. However, your registration is not complete until your team registration fee is paid. See how to pay your fees below.
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TrackMore...
Assigned Track: Foundational Advance

Title and AbstractMore...
ALeader: leading the advance of RNA synthetic biology
RNA regulation patterns, which have not been fully understood so far, is a research hotspot still deserving exploiting. A recently-discovered riboswitch ALeader updated our ideas by its delicate, 75nt-structure consisting of an aptamer, a recombination site, and even a bicistron motif. Inspired by this natural design, we proposed a series of novel strategies this summer, with dynamic rather than static perspectives. Guided by the theoretical study on functional multistable states and semi-static states of a riboswitch, and the kinetics involving impacts from other systems such as CRISPR, RNA polymerases, ribosomes, and degradation complex, the ALeader-based functional multi-phase and tricistron switches are designed. We also tried to regulate aptamer’s function by manipulating its working environment instead of itself, with SpinachALeader-based real-time monitors to avoid the signal distortion. Furthermore, to demonstrate the advantages of RNA biobricks, we constructed an antibiotic-detector with ALeader, optimized by a network with a RNA-OUT/IN translational regulatory system.

Team Roster
Primary PI   [Required]
xmding74Xiaoming Ding
Secondary PI   [Recommended] More...
None designated
Instructors
RuoyuRuoyu Luo
kazafJun Wang
Student Leaders
None designated
Student Members
Fudan_cywYanwei Cai
Quta_qbbiotheoHaotian Guo
lxykhLi Xinyi
cheese7YingQi Lou
luciewenwen-wen ni
shizhenhuShizhen Hu
ShuqiduShuqi Du
nzyZheyi Ni
WillWayWei Wei
nijiadongJiadong Ni
cxheChenxi He
luomeiMei Luo

This range of part numbers has been assigned to your team for use during the summer: BBa_K1100000 to BBa_K1100999