Synthetic Biology

based on standard parts

iGEM 2016 Team Information

Team Name: Fudan
Team Code:192596
Schools:
Fudan University
Shanghai, China
http://life.fudan.edu.cn
Kind:CollegiateApplication Date:  2016-03-06
Division:iGEMAcceptance Date: 2016-05-13 15:30:13
Region:Asia
Country:China
Section:Undergraduate

Team Registration
Your iGEM 2016 team application was accepted by iGEM Headquarters on 2016-05-13 15:30:13. However, your registration is not complete until your team registration fee is paid. See how to pay your fees below.
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Safety
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TrackMore...
Assigned Track: Therapeutics

Title and AbstractMore...
AdVENTURE: Replicative-deficient Adenovirus Targeting at Cancer Energy Pathways
Abnormally active energy pathways like glycolysis or glutamine metabolism character cancer malignant proliferation and metastasis. Researchers have managed to use chemical or biological methods to block these ways individually in vitro and achieve remarkable effect on cancer cell, but these could never be turned into practical use. We adopt safe replicative-deficient adenovirus to deliver tandem shRNAs targeted at several metabolic pathways simultaneously, which are driven by cancer-specific promoter. To test efficiency of different ways to assemble shRNAs in series, we also design a switch to control their expression in vitro. This engineered adenovirus, which we called ‘AdVENTURE’ would be a powerful and precise tool among various cancer therapies.

Team Roster
Primary PI   [Required]
TingNiTing Ni
Secondary PI   [Recommended] More...
rmzhangfudanRongmei Zhang
RuoyuLuoRuoyu Luo
Instructors
slowbeanYu An
Student Leaders
XieeeYang Xie
Student Members
DrBaoYichao Bao
sharpshooterYan Ming Zhu
evansdaiYiFan Dai
NateWangZi Yue Wang
ScorpioLihua Sun
LiuWeikangWeikang Liu
SunnyShinkiYuhui Luo
FayeJiangWen Jiang
yzwangWang Yingzhi
LeaderSheepZhengyuan Yang
gzdaijieJie Dai
Advisors
princesslxjXiaojia Liu

This range of part numbers has been assigned to your team for use during the summer: BBa_K1925000 to BBa_K1925999