Synthetic Biology
based on standard parts
iGEM 2018 Team Information
| Team Name: | Fudan |
| Team Code: | 254960 |
| Schools: | Fudan University
220 Handan Rd., Yangpu District, Shanghai, China
http://www.fudan.edu.cn/en/ |
| Kind: | Collegiate | Application Date: 2018-01-22 |
| Division: | iGEM | Acceptance Date: 2018-03-28 13:13:13 |
| Region: | Asia |
| Country: | China |
| Section: | Undergraduate
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Your iGEM 2018 team application was accepted by iGEM Headquarters on 2018-03-28 13:13:13.
However, your registration is not complete until your team registration fee is paid. See how to pay your fees below. |
| Assigned Track: Foundational Advance
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ENABLE across-membrane binary computing in mammalian cells
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| Contact-dependent signaling is critical for multicellular biological events, yet customizing contact-dependent signal transduction between cells remains challenging. Here we have developed the ENABLE toolbox, a complete set of transmembrane binary logic gates. Each gate consists of 3 layers: Receptor, Amplifier, and Combiner. We first optimized synthetic Notch receptors to enable cells to respond to different signals across the membrane reliably. These signals, individually amplified intracellularly by transcription, are further combined for computing. Our engineered zinc finger-based transcription factors perform binary computation and output designed products. In summary, we have combined spatially different signals in mammalian cells, and revealed new potentials for biological oscillators, tissue engineering, cancer treatments, bio-computing, etc. ENABLE is a toolbox for constructing contact-dependent signaling networks in mammals. The 3-layer design principle underlying ENABLE empowers any future development of transmembrane logic circuits, thus contributes a foundational advance to Synthetic Biology.
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| Primary PI [Required]
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| ripple | Daru Lu | |
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| Secondary PI [Recommended]
More...
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| wave | Liang Cai | |
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| Instructors |
| None designated
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| Student Leaders
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| Judy_Yu | Ziyan Yu | |
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| JennyDu | Rongrong Du | | |
| This range of part numbers has been assigned to your team for use during the summer: BBa_K2549000 to BBa_K2549999
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