Synthetic Biology

based on standard parts

iGEM 2018 Team Information

Team Name: Fudan
Team Code:254960
Schools:
Fudan University
220 Handan Rd., Yangpu District, Shanghai, China
http://www.fudan.edu.cn/en/
Kind:CollegiateApplication Date:  2018-01-22
Division:iGEMAcceptance Date: 2018-03-28 13:13:13
Region:Asia
Country:China
Section:Undergraduate

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TrackMore...
Assigned Track: Foundational Advance

Title and AbstractMore...
ENABLE across-membrane binary computing in mammalian cells
Contact-dependent signaling is critical for multicellular biological events, yet customizing contact-dependent signal transduction between cells remains challenging. Here we have developed the ENABLE toolbox, a complete set of transmembrane binary logic gates. Each gate consists of 3 layers: Receptor, Amplifier, and Combiner. We first optimized synthetic Notch receptors to enable cells to respond to different signals across the membrane reliably. These signals, individually amplified intracellularly by transcription, are further combined for computing. Our engineered zinc finger-based transcription factors perform binary computation and output designed products. In summary, we have combined spatially different signals in mammalian cells, and revealed new potentials for biological oscillators, tissue engineering, cancer treatments, bio-computing, etc. ENABLE is a toolbox for constructing contact-dependent signaling networks in mammals. The 3-layer design principle underlying ENABLE empowers any future development of transmembrane logic circuits, thus contributes a foundational advance to Synthetic Biology.

Team Roster
Primary PI   [Required]
rippleDaru Lu
Secondary PI   [Recommended] More...
waveLiang Cai
Instructors
None designated
Student Leaders
Judy_YuZiyan Yu
JennyDuRongrong Du
Student Members
WendyZhChuyue Zhang
vioianoLingwei Zhang
ZapperproMitchell Wan
BobooJingbo Fu
FeefeeFangfei Ye
happyzyyYuyan Zeng
Advisors
wuyaninZijie Yang

This range of part numbers has been assigned to your team for use during the summer: BBa_K2549000 to BBa_K2549999