Synthetic Biology

based on standard parts

iGEM 2018 Team Information

Team Name: Fudan-CHINA
Team Code:288676
Schools:
Fudan University
220 Handan Rd., Yangpu District, Shanghai, China
http://www,fudan.edu.cn/en/
Kind:CollegiateApplication Date:  2018-04-29
Division:iGEMAcceptance Date: 2018-04-30 09:13:05
Region:Asia
Country:China
Section:Undergraduate

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Safety
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TrackMore...
Assigned Track: Therapeutics

Title and AbstractMore...
Synthetic Transducer Engineering Platform (STEP)
Cell therapy has shown great potential in cancer treatment these years, while the existing CAR-T cell therapy can only target on cell surface antigens. However, there are also many tumour markers free in the blood, also being important targets marking the location of tumour. Here we manage to construct a brand new transducer system, named STEP, to recognise small, soluble tumour markers (e.g. VEGF, AFP, TSGF). For that purpose, we adapt and optimise a newly developed system to transduce the input (free ligands) into release of a transcription factor and expression of desired drugs. To increase the recognition ability, we use Rosetta to redesign the interface between ligand and receptor in order to enhance the binding affinity. Our STEP system can be applied for detecting tumour markers in blood and secrete drug in real time to appropriate tissues, providing a new yet practical approach for cell therapy and cancer treatment.

Team Roster
Primary PI   [Required]
rippleDaru Lu
Secondary PI   [Recommended] More...
Qiang_HuangQiang Huang
Instructors
JiaxueJiaxue Wu
weimoWei Mo
Student Leaders
EhteleZixuan Zhang
Hans_JinKaifeng Jin
Student Members
lsDrizzleXin Wang
wyfffYifan Wang
lucyyyysihan wang
kurokochanYi Wang
ZYNYineng Zhou
VesaliusLeijie Dai
SeanlieHu Haichen
Advisors
Bonnie_LiuJuan Liu
Bella_Yun Shi

This range of part numbers has been assigned to your team for use during the summer: BBa_K2886000 to BBa_K2886999