Synthetic Biology
based on standard parts
iGEM 2022 Team Information
| Team Name: | IISER_TVM |
| Team Code: | 435919 |
| Schools: | School of Biology
Indian Institute of Science Education and Research Thiruvananthapuram (IISER TVM)
Maruthamala PO, Vithura,
Thiruvananthapuram - 695551.
Kerala, India
www.iisertvm.ac.in
biology.iisertvm.ac.in |
| Kind: | Collegiate | Application Date: 2022-04-20 |
| Division: | iGEM | Acceptance Date: 2022-06-15 11:25:25 |
| Region: | Asia |
| Country: | India |
| Section: | Undergraduate
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Welcome to iGEM 2022 ! Your iGEM 2022 team application was accepted by iGEM Headquarters on 2022-06-15 11:25:25. |
| Assigned Track: Therapeutics
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Duonco: A dual nanovesicle drug delivery system targeting breast cancer
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| Poor specificity is a fundamental issue with contemporary cancer drug therapy, necessitating improved alternatives. We have conceptualized and developed Duonco, a dual nanovesicle drug delivery system to address breast cancer, a growing concern in our community. Duonco targets HER2 and CX3CR1, two cell surface markers over-expressed in HER2+ breast cancer. We bioengineered E. coli to produce two distinct outer membrane vesicles (OMVs) populations, to selectively deliver chemotherapeutic prodrugs and their cognate enzymes, respectively, into tumour cells. This system is developed such that it functions analogous to an AND gate, where the drug is only activated in cells that overexpress both markers, and remains inactivated or undelivered in normal cells. Using hypervesiculating strains of E. coli, we have generated OMVs expressing anti-HER2 or anti-CX3CR1 affinity proteins on their surface and characterized them. We propose that such an adaptable system has immense potential for cell-specific targeting as well as in personalized medicine.
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| Advisors
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| Abhi123 | Abhishek Raghunathan | |
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| This range of part numbers has been assigned to your team for use during the summer: BBa_K4359000 to BBa_K4359999
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